For Cellular Protection and Optimal Hormone Balance

60 capsules , #809, $29.95

It is a sad fact that the very hormones we need to stay young can cause adverse effects as we age. Consumption of cruciferous vegetables, however, can favorably alter one's hormone profile.

Scientists have identified specific extracts from cruciferous vegetables (broccoli, cauliflower, Brussels sprouts, etc.) that modulate hormones in a way to help maintain healthy cell division. For instance, animal studies have shown that the cruciferous vegetable extract indole-3-carbinol (I3C) modulates estrogen hormones by favorably changing the ratio of protective 2-hydroxyestrone versus the damaging 16-hydroxyestrone.1 Indole-3-carbinol also induces phase I and II detoxifying enzymes that can help neutralize estrogen metabolites and xenobiotic estrogen-like environmental chemicals.2 Human studies support the beneficial role of I3C in positively altering estrogen metabolism.3 Di-indoyl-methane (DIM), a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging estrogen called 4-hydroxyestrone.4

The glucosinolates are major constituents of cruciferous vegetables that have been shown to promote normal apoptosis and induce the expression of the beneficial p53 gene via an estrogen-independent action.5

Watercress contains isothiocyanates, but in a broader spectrum than does broccoli. The primary isothiocyanate precursor (PEiTC) in watercress functions via four specific mechanisms to maintain healthy cell division.6 Extracts from rosemary enhance liver metabolism of estradiol and estrone,7 inhibits the formation of DNA adducts,8 and have been shown to impede estrogen-induced growth promotion in certain tissues.7

Based on a growing body of evidence that cruciferous vegetable extracts (in addition to I3C) provide bountiful health benefits, Life Extension has reformulated its I3C supplements to more closely resemble what one would obtain from a vegetable-rich diet.

For those weighing less than 160 pounds, just one capsule a day of Dual-Action Cruciferous Vegetable Extract provides optimal potencies. Those weighing over 160 pounds should consider taking two capsules per day.

1. Biochem Pharm. 2002, 64;393-404.
2. Toxicol Appl Pharm. 2001 Jul 15;174(2):146-52.
3. J Natl Cancer Inst. 1997 May 21;89(10):718-23.
4. Cancer Detect Prevent. 2004;28:72-9.
5. Carcinogenesis. 2002 Apr;23(4):581-6.
6. Mol Cancer Ther. 2003 Oct;2(10);1045-52.
7. Carcinogenesis. 1998 Oct;19(10):1821-7.
8. Carcinogenesis. 1995 Sep;16(9):2057-62.

Supplement Facts
Serving Size 1 capsule
Servings Per Container 60

Amount Per Serving
Broccoli .................................................400 mg
(Brassica oleracea l.) Super Concentrate Extract (plant and sprouts)
[standardized to 4% glucosinolates (16 mg)]

Watercress (leaf)....................................100 mg
(Nasturtium officinale) 4:1 Extract

Indole-3-Carbinol (I3C)...............................80 mg

Rosemary................................................50 mg
(Rosmarinus officinalis) Extract (leaves)
[standardized to 20% diterpenic compounds (10 mg) and providing carnosic acid/carnosol]

DIM (Di-indolyl-methane)...........................14 mg

Other ingredients: gelatin, rice flour, magnesium stearate, maltodextrin, titanium dioxide.

This product contains NO wheat, yeast, gluten, corn, or dairy. Contains NO sugar, artificial sweeteners, flavors, colors, or preservatives.

Dosage and Use
One capsule daily for individuals weighing up to 160 pounds.

Those weighing over 160 pounds, take two capsules daily.

This product can be taken with or without food.

Caution
May interfere with oral contraceptives. If pregnant or intending to become pregnant, do not use this product. Do not use if taking antacids, H2-receptor blockers (e.g. Zantac ®), or proton-pump inhibitors (e.g. Nexium®), as these drugs may impede the conversion of I3C to active metabolites.

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